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LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT
Descriptors Found:
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DeCS
Descriptor
English
:
Leukemia Inhibitory Factor Receptor alpha Subunit
Descriptor
Spanish
:
Subunidad alfa del Receptor del Factor Inhibidor de Leucemia
Descriptor
Portuguese
:
Subunidade alfa de Receptor de Fator Inibidor de Leucemia
Synonyms
English
:
Antigens, CD118
CD118 Antigens
Tree Number:
D12.776.543.750.705.852.500.750
D12.776.543.750.705.852.555.800.750
D12.776.543.750.750.400.550.250.750
D23.050.301.264.035.493
D23.101.100.110.493
Definition
English
:
A receptor subunit that combines with
CYTOKINE RECEPTOR GP130
to form the dual specificity receptor for
LEUKEMIA INHIBITORY FACTOR
and
ONCOSTATIN M
. The subunit is also a component of the
CILIARY NEUROTROPHIC FACTOR
RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to
ALTERNATIVE SPLICING
of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
History Note
English
:
2007
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52379
Unique Identifier:
D053680
Occurrence in VHL
:
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DeCS
CID-10
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